Just a proposition or recommendation of sorts...
Recently I've came across the gameboyJam site:
http://jams.gamejolt.io/gbjam3/gameshttp://jams.gamejolt.io/gbjam4/games...and also have a look at the real gameboy games...
The 160x144 4color graphic mode has a real charm... at least for me.
...and the ep is capable of it.
You can have 160x144 4color with LPIXEL or CHAR modes.
A single screen buffer takes $1680 bytes when no scrolling. That's not much so you could preapre a clean buffer for speeding up the erasing of sprites. Could be quite fast. Don't know about using char mode but it is a possibility.
The downsides are that although you have wide pixels, the scroll would be in 4 pixel chunks... not very elegant. Also you would need more shifted sprites. Most TVs won't display some of the vertical lines so the hud may not be visible.
And with the nick's rich 256 color palette one could find some good 4-color themes.
Any other pros/cons?
PS: look at the game
http://jams.gamejolt.io/gbjam3/games/stasis/31945 - this is a simple game that's certainly possible on the ep. Or look at the classic tetris for gb or maybe the duffy duck martian missions.