I would like (most of Zozo's stuff, not mentioning them again (hopefully):
* SD card (well, we have the "standard" cartridge now, but if "all-in-one" let's name that way, so no need for other components to buy/use!)
* Ethernet solution, possibly something like wiznet w5300 chip (MSX/SymbOS world seems to be interested in wiznet chips as well)
* general SPI bus solution (also usable fog eg SD-card) so other SPI slave devices can be connected and used (even like MPEG audio codec IC over SPI to be able to play MP3s, the SymbOS demos on MSX use something like that, of course a Z80 can't decode MP3 in real time ..... and those ICs are not so expensive able to work in more primitive mode too, ie simple sample playback, etc - but numerous examples exist even kind of odd things with SPI)
* DAC maybe configurable to 16 bit mode as well over only 2*8?
(oh, and about some "codec ICs" may do functions like plain DAC and hardware decoding MP3/vorbis/etc as well)
* even more odd idea: USB host to be able to use mass-storage class devices at least (pen drives, even HDDs with converters if some really wants, digital cameras and cell/smart phones using this protocol etc). Sometimes even sounds better than having SD card interface
I am not sure about these:
* some PS/2 (?) mouse interface? - maybe easier to do externally to be able to use PS/2 mouse and have boxsoft-like (compatible) signaling, etc
* some PS/2 (?) keyboard interface (it's a bit complex topic and no really usable solution exist still, it seems which is kinda sad in my opinion)
What I (personal opinion!) can live without:
* IDE/HDD: SD card is big enough for "retro", much more easy to handle etc
* floppy/FD: I never liked floppies
* serial/UART stuff
Personally I think network (ethernet) is even more important than SD, ie network storage then, instead of SD card which should be swapped between EP and the PC all the time
Especially if some wants to develop something with rapid testing cycles.
And BTW, a PCB between Z80 and its socket so we can "convert" I/O port accesses. For example real Spectrum emulator, not with the NMI-when-keyboard etc. Ok, this is another topic already