EnterMice returns two bytes for the movement, on
two's complements for the Z80 processor. You can add them directly to the actual position, checking what happens to the flags to correct the coordinates if the addition is lower or higher than your playing zone.
Two's complements is a convention to represent a whole signed number. The Z80 works with sign when the appropriate operant is selected. Bit 7 set indicates a negative bit, but you can't take the rest of the bits as the data, only in positive numbers happens this, because negative numbers start from 255(1111 1111) as -1 backwards up to 128(1000 0000) as -128.
But the magic is that adding a pair of two's complement numbers works... if the result don't exceeds the +127 -128 range...